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AKCCHF grant #610

Evaluation of Genetic Markers for Diabetes Mellitus in Samoyed and Australian Terrier Dogs

Samoyed enrollment for this study is CLOSED.  SCARF wishes to thank the efforts of many Samoyed owners for contributing to this research study.

Samoyed Club of America Education & Research Foundation, Inc., Australian Terrier Club of America, , San Joaquin Kennel Club

Rebecka S. Hess, DVM, DACVIM, University of Pennsylvania School of Veterinary Medicine

Samples are still needed for a study of diabetes in Samoyeds.  Dr. Hess needs blood samples from diabetic Samoyeds.   

In a retrospective study  on diabetes mellitus (DM), Dr. Hess found that Samoyeds were 12 times more likely to develop DM than mixed dog breeds. (click here for abstract)

Note:  Shipping of the sample will be pre-paid by the researcher via Fed-Ex at NO expense to you.  Click here for more information on how to participate.

Print out a letter to take to your veterinarian which explains the study details - click here.

Samoyed Questionnaire for Dr. Hess

Note: You will need Adobe Reader to view & print our .pdf files (FREE download).

Abstract of current study from the AKCCHF website:
"Canine diabetes mellitus (DM) is a common disorder of middle to older age dogs. Samoyed and Australian Terrier dogs are at increased risk for DM. The most important genes involved in the pathogenesis of type I DM in humans are the major histocompatibility complex class II (MHC-II) genes and the insulin gene region. The objectives of this study are to determine if specific allelic variations in the MHC-II and insulin gene region occur more commonly in diabetic Samoyeds or Australian Terriers compared to non-diabetic Samoyeds or Australian Terriers. DNA from 150 Samoyeds and 150 Australian Terriers will be purified and PCR of the MHC-II region and the insulin gene region will be performed. PCR products will be purified and sequenced. Single nucleotide polymorphisms (SNP) will be studied in the regions of the MHC-II genes and the insulin gene, in order to determine if there are differences in allele frequencies of diabetic dogs compared to control dogs. Identification of possible genetic markers associated with DM in young, unaffected, breeding dogs will enable breeders to determine which dogs should not be bred to one another years before the onset of DM. This may help prevent DM in Samoyeds and Australian Terriers."

For more information on diabetes, click here.





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